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700

700

series 

★　★　★

> Maximum flexibility   
> Dual electrode

> Multiple pumps and detectors
> Pulse-free pump

＋＋＋＋＋＋＋＋

Expandability is the keyword for the 700 Series.

Extra pumps and detectors can be added as necessary.　The standard configuration includes the ECD-700 detector equipped with one amperometric cell, the EP-700 pump unit with one microflow pump installed, and the ATC-700 temperature control unit, The pump unit also has a two channel solvent degasser built in.

Electrochemical Detector

ECD-700

ECD

ECD-700

​【Electrochemical Detector】​

feature

> Add an ECD to any HPLC system​

> Two cells per detector possible​

> Amperometric or coulometric cells​

> Dual electrode

Standard Features

  • Superior sensitivity and stability of Eicom’s electrochemical detector technology.

  • Easy to maintain.

  • Maximized up-time.

  • One amperometric electrochemical detector cell with a constant voltage configuration using the same type of flow cell as the HTEC-510.

  • Available materials of working electrode; graphite, pure graphite, glassy carbon, platinum, gold, silver.

  • Easy access to the working electrode.

ECD-700 

Electrochemical Cell               
Amperometric with 3 electrode DC potentiostat (standard): Space for optional
 
second cell (optional)
Coulometric or amperometric

Working Electrode
Graphite composite(standard),glassy carbon, pure graphite, platinum, gold,
silver

Optional Dual Electrode
Glassy carbon, graphite composite (both use a shared reference)

Reference Electrode
Ag/AgCl

Counter Electrode
316 stainless steel

Applied Voltage Range
-2000mV to +2000mV, 1mV increments

Auto Zero Function
Between -1000 nA and + 1000 nA: triggered by external input

​★

★

HPLC Pump Unit

EP-700

EP

EP-700

​【HPLC Pump】​

> Pulse quenching by computer control

> Two channel degasser included

> No pulse damper necessary

> Gradient control built in

EP-700 

​Pressure Limit

20Mpa

Micro Flow Pump

100μL/min, 1μL increment, 4μL/stroke

​High Flow Pump

0.5 - 3.0 mL/min, 0.01 mL increments, 32μL/ stroke

Wetted Surfaces

PEEK, Sapphire, Ruby PCTFE

Special Features

Gradient control built in, input signal for star / stop

Built-in Degasser

2channels: 300μL volume/ ea, up to 3.0 mL/min

Temperature Controller

ATC-700

ATC

ATC-700

​【Temperature】​

ATC-700

Temperature control provides the most stable retention times and detector signals.The ATC-700 performs this function even at room temperature due to its ability to both heat and cool.

​

Temperature Range

15-55℃, 1℃ increments, 20-45℃ (Recommended range)

size：  400 (w) x 400 (d) x 145 (h) cm。

weight 10 kg。

AC 100-240 V, 50/60 Hz, 210 VA

​Electrochemical detector
Oral acetaminophen-induced spinal 5-hydroxytriyptamine release produces analgesic effects in the rat formalin test

l-Menthol increases extracellular dopamine and c-Fos-like immunoreactivity in the dorsal striatum, and promotes ambulatory activity in mice

Photoperiodic light pulse induces ovarian development in the catfish, Mystus cavasius: Possible roles of dopamine and melatonin in the brain

Substantial acetylcholine reduction in multiple brain regions of Mecp2-deficient female rats and associated behavioral abnormalities

5-HT2B Receptors-triggered Serotonin Release from Guinea-pig Isolated Colonic Mucosa：a Role of Endogenous Peptide YY

Viability of diffuse large B-cell lymphoma cells is regulated by kynurenine 3-monooxygenase activity

Repeated oral administration of flavan-3-ols induces browning in mice adipose tissues through sympathetic nerve activation

Administration of cyclophosphamide to rats induces pica and potentiates 5-hydroxytryptamine synthesis in the intestine without causing severe intestinal injury

The Effects of Maternal Interleukin-17A on Social Behavior, Cognitive Function, and Depression-Like Behavior in Mice with Altered Kynurenine Metabolites

Hair-Follicle-Associated Pluripotent (HAP) Stem Cells Can Extensively Differentiate to Tyrosine-Hydroxylase-Expressing
Dopamine-Secreting Neurons

Tyrosine hydroxylase conditional knockout mice reveal peripheral tissue-dependent differences in dopamine biosynthetic pathways

Bumble bee queens activate dopamine production and gene expression in nutritional signaling pathways in the brain

2020
Dopamine production in the brain is associated with caste-specific morphology and behavior in an artificial intermediate honey bee caste

Mirtazapine exerts astrocyte-mediated dopaminergic neuroprotection

Maternal dietary imbalance between omega-6 and omega-3 fatty acids triggers the offspring’s overeating in mice

Interaction between Mesocortical and Mesothalamic Catecholaminergic Transmissions Associated with NMDA Receptor in the Locus Coeruleus
Thioredoxin as a novel sensitive marker of biological stress response in smoking

Kynurenine plays an immunosuppressive role in 2,4,6-trinitrobenzene sulfate-induced colitis in mice

The Role of Serotonin in the Influence of Intense Locomotion on the Behavior Under Uncertainty in the Mollusk Lymnaea stagnalis

Blockade of the renin-angiotensin system suppresses hydroxyl radical production in the rat striatum during carbon monoxide poisoning

Serum Metabolic Profiles of the Tryptophan-Kynurenine Pathway in the high risk subjects of major depressive disorderShati/Nat8l deficiency disrupts adult neurogenesis and causes attentional impairment through dopaminergic neuronal dysfunction in the dentate gyrus Running title: Impaired neurogenesis in the Shati/Nat8l-/- mice 2020

Melatonin inhibits reproductive activity through changes of serotonergic activity in the brain of freshwater catfish (Mystus cavasius)

Electrochemical Molecular Beacon for Nucleic Acid Sensing in a Homogeneous Solution

An ultra-stable cytoplasmic antibody engineered for in vivo applications

Analysis of the source of aggressiveness in gamecocks

Serotonergic control in initiating defensive response to unexpected tactile stimulus in the trap-jaw ant Odontomachus kuroiwae

2019
Effect of Yokukansan and Yokukansankachimpihange on Aggressive Behavior, 5-HT Receptors and Arginine Vasopressin Expression in Social Isolation-Reared Mice

Serotonin uptake via plasma membrane monoamine transporter during myocardial ischemia-reperfusion in the rat heart in vivo

Selegiline Recovers Synaptic Plasticity in the Medial Prefrontal Cortex and Improves Corresponding Depression-Like Behavior in a Mouse Model of Parkinson’s Disease

A Redox-Inactive Derivative of Tocotrienol Suppresses Tumor Growth of Mesothelioma Cells in a Xenograft Model

Iso-a-acids, the bitter components of beer, improve hippocampus-dependent memory through vagus nerve activation

2018
Prefrontal cortex miR-874-3p prevents lipopolysaccharide-induced depression-like behavior through inhibition of indoleamine 2,3-dioxygenase 1 expression in mice.
 
Comparison of the sympathetic stimulatory abilities of B-type procyanidins based on induction of uncoupling protein-1 in brown adipose tissue (BAT) and increased plasma catecholamine (CA) in mice

Caste-specific development of the dopaminergic system during metamorphosis in female honey bees

Functional mechanism of ASP5736, a selective serotonin 5-HT5A receptor antagonist with potential utility for the treatment of cognitive dysfunction in schizophrenia

2017
Individual differences are consistent across changes in mating status and mediated by biogenic amines

Chronopharmacological Analysis of Antidepressant Activity of a Dual-Action Serotonin Noradrenaline Reuptake Inhibitor (SNRI),Milnacipran, in Rats

2016
Differential Patterning of Genes Involved in Serotonin Metabolism and Transport in Extra-embryonic Tissues of the Mouse

2015
Hepatic resistance to cold ferroptosis in a mammalian hibernator Syrian hamster depends on effective storage of diet-derived α-tocopherol

A study on Dowager Cixi’s Yanling-Yishou-Dan of Qing Dynasty in a Japanese laboratory of biochemistry and molecular biology in 1990s: An attempt for TCM modernization¤
 
Monitoring Of Blood L-DOPA And L-DOPA Metabolite Concentrations And Adverse Events In Patients With Advanced Parkinson’s Disease Receiving L-DOPA And Amantadine Combination Therapy: A Clinical Study

Glutamate Input in the Dorsal Raphe Nucleus As a Determinant of Escalated Aggression in Male Mice

Placental Tryptophan Metabolism: A Novel Pathway for the Developmental Origins of Neurological Disorders

2014
Enhancement of Energy Expenditure following a Single Oral Dose of Flavan-3-Ols Associated with an Increase in Catecholamine Secretion

2012
Serotonin2C receptors in the nucleus accumbens are involved in enhanced alcohol-drinking behavior

Tyrosine hydroxylase gene expression is facilitated by alcohol followed by the degradation of the protein by ubiquitin proteasome system

Role of Inter-Leukin-13 (IL 13), Natural killer (NK-CD57) cells and Non Neural Acetyl choline (NNAC) in patients with Fusobacterium varium colonized Ulcerative Colitis in Specialized Medical Hospital “SMH”

2009
Auditory Stimulation Dishabituates Olfactory Responses via Noradrenergic Cortical Modulation

Placental Transport and Metabolism: Implications for the Developmental Effects of Selective Serotonin Reuptake Inhibitors (SSRI) Antidepressants
 

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